Q1 · Cyclophosphamide Toxicity
NEET PGMediumHaemorrhagic cystitis caused by cyclophosphamide is prevented by co-administering?
Explanation
Cyclophosphamide's metabolite acrolein irritates the bladder, causing haemorrhagic cystitis. Mesna binds and inactivates acrolein in the urine, preventing this. Adequate hydration also helps.